NUI Galway will host a research seminar presented by Nobel laureate, Professor Paul Modrich of Duke University Medical Center and the Howard Hughes Medical Institute in the US. Professor Modrich will talk about ‘Mechanisms in human DNA mismatch repair’.

Professor Paul Modrich was one of three scientists to share the Nobel Prize in Chemistry in 2015 for landmark discoveries over four decades of work in DNA repair. His host at NUI Galway, Professor Robert Lahue, trained as a postdoctoral fellow in Modrich’s laboratory. The Nobel Committee cited one of the Lahue-Modrich publications as groundbreaking.

The Nobel Committee recognised Professor Modrich’s work on mismatch repair, which acts as a genetic spellchecker to preserve the DNA. Defects in mismatch repair are now known to cause certain hereditary forms of colorectal cancer. Genetic testing of cancer patients helps identify those with mismatch repair defects, providing information, which is important in guiding their treatment.

Professor Robert Lahue from the Centre for Chromosome Biology at NUI Galway, said: “The research community at NUI Galway is tremendously excited about Professor Modrich’s visit and seminar. He is a world leader in the area of DNA biochemistry and cancer biology. We are fortunate to have him visit, to present a seminar and to interact with members of our Centre and other researchers at NUI Galway.”


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